Reserve concomitant prescribing of such medicines in individuals for whom other therapy choices are insufficient. Restrict dosages and durations on the least expected. keep track of closely for signs of respiratory despair and sedation.
conivaptan will enhance the stage or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/watch.
grapefruit will boost the level or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/keep track of.
apalutamide will minimize the extent or impact of diazepam by affecting hepatic enzyme CYP2C19 metabolism. keep away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with prescription drugs which might be CYP2C19 substrates can result in lower publicity to these medicines.
Diazepam is N-demethylated by CYP3A4 and 2C19 for the active metabolite N-desmethyldiazepam, and is also hydroxylated by CYP3A4 towards the active metabolite temazepam. N-desmethyldiazepam and temazepam are equally further metabolized to oxazepam. Temazepam and oxazepam are mostly eliminated by glucuronidation.
levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will enhance the stage or effect of diazepam by lowering metabolism.
Metabolism: Diazepam is usually broken down with the microsomal enzymes CYP2C19 and CYP3A4 enzymes to numerous Lively metabolites, largely desmethyldiazepam.
Inappropriate habits and also other adverse behavioral results are documented when applying benzodiazepines. click here should really these take place, use from the drug needs to be discontinued. They are more likely to manifest in youngsters and inside the aged.
get in touch with your Health care provider straight away Should you have any of such signs and symptoms, especially if They may be new, worse, or worry you:
A decision to prescribe diazepam rectal gel entails over the diagnosis and collection of correct dose
marijuana will raise the stage or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/observe.
Comment: Teduglutide could improve absorption of concomitant PO medicines; caution with with medicines requiring titration or These using a slim therapeutic index; dose adjustment might be vital.
Reserve concomitant prescribing of such medications in patients for whom other treatment method solutions are insufficient. Restrict dosages and durations on the minimal necessary. keep track of closely for signs of respiratory despair and sedation.
stiripentol will minimize the extent or impact of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/keep an eye on Closely. take into account lowering the dose of CYP2C19 substrates, if adverse reactions are professional when administered concomitantly with stiripentol.